Use Cases

Genomic architecture of inflammatory bowel disease in five families with multiple affected individuals

This Big Data Spokes Project aims to speed our understanding of genetic variants that are suspected of causing disease by instantly showing researchers a 3D model of the chemical effect of each variant. Because determining these effects is currently a laborious process requiring specialized skills, it is often not done in research on genetic variants. Here, we present a study of the genetic causes of inflammatory bowel disease, and show how our resource could have been employed to make the study faster and cheaper.